Brain Tumors

Facing a brain tumor diagnosis in childhood

Important. This is general educational information. Your child's situation is unique. Always talk to your child's treating doctor for advice that fits your child specifically.

To be told that your child may have a brain tumor is among the most difficult news a parent can be given. This page exists to put the words and the journey into plain language - what your doctors mean when they use the term, what tests will follow, what the treatment involves, and what the path through it tends to look like. The information here is general, your child's neurosurgeon and oncologist will discuss what applies to your child specifically.

What is a brain tumor?

A brain tumor is a growth of abnormal cells in the brain or in the structures around it. The word "tumor" is broad, it covers many different conditions and each has its own outlook. Some grow slowly and may be cured by a single operation, others behave more aggressively and need a combination of treatments. The first task of your child's team is to work out exactly which type of tumor your child has.

Paediatric brain tumors are not the same as those seen in adults. Children develop their own specific types, often in different regions of the brain, and they respond to treatment differently. This is why a child with a brain tumor is best cared for by a team that has specific experience in paediatric brain tumors.

Tumors are described as benign (slow-growing, less likely to spread) or malignant (faster-growing, often requiring more intensive treatment). An important point about the brain - even a benign tumor can cause significant problems if it presses on a critical area, and many malignant paediatric tumors today respond very well to treatment.

Names you may hear from the team include medulloblastoma, low-grade glioma (sometimes called pilocytic astrocytoma), ependymoma, craniopharyngioma, germ cell tumor, or high-grade glioma. Each is a separate diagnosis with its own treatment pathway and its own outlook. It is worth asking the team to write the exact name down for you, the precise diagnosis is what determines the plan and the prognosis, and it helps you find accurate information online.

Signs you might notice

The symptoms of a brain tumor in a child depend on the age, the location of the tumor and the speed at which it is growing. Many of the symptoms listed below are non-specific and can have entirely different causes, but anything that is persistent or worsening needs to be reviewed by a doctor.

In babies

  • Head growth that is faster than expected at routine measurements
  • A bulging or tense anterior fontanelle (the soft spot on top of the head)
  • Repeated vomiting without an apparent cause
  • Unusual sleepiness, irritability, or difficulty feeding
  • Eyes that drift downwards (the "sunsetting sign") or that do not move together
  • Losing skills the baby had already gained, or falling behind on developmental milestones
  • Seizures

In older children

  • Morning headaches, frequently associated with vomiting
  • Vomiting in the morning, sometimes occurring without preceding nausea
  • Increasing tiredness, drowsiness, or difficulty rousing from sleep
  • New problems with balance, walking, or fine coordination
  • Visual disturbance - double vision, blurring, or loss of portions of the visual field
  • New weakness on one side of the body, or an unexpected change in hand preference
  • Seizures - a first seizure in a child should always be evaluated
  • Decline in school performance, changes in personality, or loss of previously learned abilities
  • When the tumor involves the pituitary region: abnormal growth pattern (too rapid or too slow), unusually early or delayed puberty, or excessive thirst with frequent urination

How is it diagnosed?

The first and most useful test is an MRI of the brain. The MRI uses a strong magnet (with no radiation) to produce detailed images of the brain anatomy. Your child will need to be still throughout the scan, younger children often require light sedation or a brief general anaesthetic to achieve this. The MRI is typically performed without and then with intravenous contrast (gadolinium), which highlights tumor tissue and makes its borders clearer.

A CT-scan of the head is sometimes performed first, in particular in an emergency setting, because it is fast. CT uses a small dose of X-ray radiation. It is good at picking up bleeding or any sudden change, but the MRI gives a much clearer picture of the tumor itself.

The images often point towards a particular type of tumor, but they cannot be the final word. A tissue sample is required in most cases - either through a biopsy (a small piece taken with a needle) or by removing the tumor in an operation. The tissue is then examined under the microscope and sent for laboratory testing.

Modern brain tumor diagnosis is no longer based on the microscope alone. Tumors are now also tested for specific molecular markers - features of the tumor's DNA that tell us a great deal about how it will behave and which treatments are likely to be effective. The current world classification (WHO 2021) combines the microscopic findings with these molecular results. This is why the final diagnosis after surgery can take a week or more, the team is waiting for the complete picture to be assembled.

Depending on the tumor type, your child may also need an MRI of the whole spine and a sample of cerebrospinal fluid (CSF) to assess whether the tumor has spread. Certain tumors additionally require blood tests for hormones or tumor markers.

How is it treated?

Treatment is nearly always tailored to the specific tumor type, the child's age, and the tumor location. The care of these children is delivered by a multidisciplinary team - a paediatric neurosurgeon, a paediatric oncologist, a radiation oncologist, paediatric neurology, endocrinology, neuropsychology, rehabilitation, and a nurse coordinator who keeps everything connected. Most treatment plans use a combination of the approaches outlined below.

Surgery

For the majority of paediatric brain tumors, surgery is the first step. The neurosurgeon's aims are three: to relieve any mass effect on the brain, to remove as much of the tumor as is safe, and to obtain tissue for the definitive diagnosis. The amount that can be safely removed depends largely on where the tumor sits - some tumors can be entirely taken out and may not need any further treatment, others sit in areas where attempting complete removal would be too risky. For certain tumors a biopsy alone is sufficient, while for others (such as some deep brainstem lesions) surgery is not safe and the diagnosis is established by other means.

Chemotherapy

Chemotherapy refers to medications that target tumor cells. In paediatric brain tumors it is used both for malignant lesions and, more frequently in recent years, for some low-grade tumors - to delay or to avoid radiation in younger children. Chemotherapy is given in cycles over months, in some cases for more than a year. The side effects depend on the specific medications used and are managed by the paediatric oncology team.

Radiation therapy

Radiation therapy uses focused beams of energy to treat tumor cells that surgery cannot reach. It is a highly effective tool for many brain tumors. In children it is used with caution, particularly in the very young, because the developing brain is more sensitive to its long-term effects. When radiation is needed, modern techniques (such as proton therapy where available) allow the dose to be focused on the tumor while sparing more of the surrounding healthy brain tissue.

Targeted therapies

For certain tumors the molecular tests now point to medications that target the exact genetic change driving the disease - for example, BRAF and MEK inhibitors for some low-grade gliomas, including in children with neurofibromatosis type 1 (NF1). These medications are taken orally at home, often over many months, and they have transformed the treatment landscape of some paediatric brain tumors over the past decade.

Watch and wait

Not every brain tumor requires immediate intervention. Some very slow-growing tumors that are causing no symptoms can be safely watched with serial MRI scans. This is an active treatment choice and not a passive one, it may well be the right option for your child. The team will explain the reasoning when it applies to your situation.

Treating raised pressure (hydrocephalus)

Some brain tumors obstruct the flow of cerebrospinal fluid and cause hydrocephalus - a build-up of fluid within the brain. This may require its own treatment, either through removal of the tumor itself or by placing a drain (such as an ETV or a shunt), temporary or permanent. The hydrocephalus page on this site goes into more detail.

Your child's case will be discussed at a tumor board - a regular meeting where neurosurgery, oncology, radiation oncology, radiology and pathology review the case together and agree on the management plan. Ask the team if you would like to know the recommendations that come out of that meeting.

What can we expect?

Treatment for a brain tumor tends to be a journey rather than a single event. After the surgery, your child will spend some time in the paediatric intensive care unit (PICU) and then move to a regular ward. The hospital stay after a brain tumor operation is generally longer than for other surgeries - typically several days to a couple of weeks - while the team monitors for swelling, confirms that the fluid pathways are working, and starts the rehabilitation process.

Some children, particularly those who have had surgery in the back part of the brain (the posterior fossa), can experience temporary difficulties with speech, swallowing, or movement in the days and weeks after the operation. This is known as posterior fossa syndrome (or cerebellar mutism syndrome). It is frightening for families to see, but in most children it improves over the following weeks to months with rehabilitation. The team will let you know in advance if this is a particular risk for your child.

When chemotherapy or radiation is required after surgery, the next phase of treatment can extend over many months and will be managed largely by the paediatric oncology team. There will be regular clinic visits, blood tests, MRI scans on a defined schedule, and at times inpatient admissions for treatment or for the management of side effects. It is demanding work - for the child and for the family - and the team will help with planning around school, work, and daily life.

Once active treatment is complete, your child will continue with follow-up for many years, often into adulthood. The long-term follow-up watches the tumor itself (through MRI scans) as well as the areas that treatment can affect - growth and hormones, hearing, vision, learning, mood, and fertility. This careful long-term follow-up is one of the reasons that outcomes for paediatric brain tumors have improved substantially over recent decades.

The prognosis depends heavily on the specific tumor type. Some children are cured with the first operation and need no further treatment. Many children with malignant paediatric brain tumors today go on to live long and full lives. Some tumors remain very difficult to treat, and the team will be honest with you about what they expect. Whatever the situation, the aim is not just to treat the tumor but to support your child's development, schooling and overall quality of life. Families going through this are not alone - paediatric neurosurgery and neuro-oncology teams, family support organisations, and other families who have travelled this path are all available to you.

Questions you might ask your child's doctor

  • What is the exact name of my child's tumor, and can you write it down for me?
  • Where is the tumor situated, and what regions of the brain does it involve?
  • Is this tumor benign or malignant, and what does that mean for my child specifically?
  • Which molecular tests will be performed on the tumor, and how long before we have the full result?
  • What treatment plan are you recommending, and why? Are there other reasonable options we should consider?
  • Will my child need surgery, chemotherapy, radiation, or a combination of these? What is the sequence and timeline?
  • What are the specific risks of the surgery, and what deficits could it potentially cause?
  • What long-term effects of the treatment should we watch for as our child grows?
  • Who is on the team, and who do we contact between appointments? Is there a nurse coordinator we can call?
  • What support is available for the siblings, the school, and the family as a whole?

When to call your child's doctor right away

During and after treatment for a brain tumor, certain signs can indicate a serious problem - raised pressure within the brain, a complication of the treatment, or an infection. Do not wait, contact the neurosurgery or oncology team (or go straight to the emergency department) right away if you notice any of the following:

  • A worsening headache, especially when associated with vomiting
  • Persistent vomiting that does not stop
  • Unusual drowsiness, difficulty rousing, or confusion
  • A seizure, or any change from your child's usual seizure pattern
  • New weakness on one side, new difficulty walking, or a sudden balance problem
  • New or worsening visual symptoms
  • Difficulty swallowing, a weak cough, or any changes in breathing
  • In a baby - a tight or bulging fontanelle, accelerated head growth, or downward-deviation of the eyes
  • Redness, swelling, fluid leaking, or pain at the surgical wound
  • In a child on chemotherapy - a fever of 38°C (100.4°F) or above, this can indicate a serious infection and needs urgent attention

If your child is difficult to wake, is having a seizure, or is having difficulty breathing, this is an emergency, go to the nearest emergency department or call the emergency services straight away.

More information from trusted sources

  • Together by St. Jude Children's Research Hospital — A high-quality plain-language resource from St. Jude aimed at families of children with cancer. It includes detailed pages on paediatric brain tumors, treatment options, side effects, school, and long-term follow-up. Free, and available worldwide.
    https://together.stjude.org ↗
  • National Brain Tumor Society — A US-based non-profit providing patient and family information across many brain tumor types, with a dedicated paediatric section and links to support and ongoing research.
    https://braintumor.org ↗
  • The Brain Tumour Charity (UK) — A UK charity providing high-quality plain-language information for families. It has a dedicated children and families section as well as an active support line.
    https://www.thebraintumourcharity.org ↗
  • American Association of Neurological Surgeons — Patient Information — The patient education pages of the American Association of Neurological Surgeons, with overviews of paediatric brain tumors and related conditions written in plain language.
    https://www.aans.org/Patients/Neurosurgical-Conditions-and-Treatments ↗
  • HealthyChildren.org (American Academy of Pediatrics) — Trusted patient and family information from the American Academy of Pediatrics, covering a wide range of paediatric conditions including childhood cancer and brain tumors.
    https://www.healthychildren.org ↗