For educational use. These tools are intended for reference and education. All care decisions require a direct clinical assessment of the patient and independent verification of doses and values by the treating team.

Glasgow Coma Scale (GCS)‎

The standard assessment of the level of consciousness. For patients aged ≥ 5 years. Use the paediatric version (PGCS) below for younger or pre-verbal children.

15
Total GCS
Minor injury (13–15)‎
Source: Teasdale G, Jennett B. Assessment of coma and impaired consciousness. A practical scale. Lancet 1974;2(7872):81–84. PMID 4136544 · doi:10.1016/s0140-6736(74)91639-0

Pediatric Glasgow Coma Scale (PGCS)‎

An adaptation of the GCS for children under about 5 years of age or who are pre-verbal. Only the Verbal component differs, the Eye and Motor components are the same as the standard GCS.

15
Total PGCS
Minor injury (13–15)‎
Source: Simpson D, Reilly P. Pediatric coma scale. Lancet 1982;2(8295):450. PMID 6124846 · doi:10.1016/s0140-6736(82)90486-x
Original GCS: Teasdale G, Jennett B. Assessment of coma and impaired consciousness. A practical scale. Lancet 1974;2(7872):81–84. PMID 4136544 · doi:10.1016/s0140-6736(74)91639-0

ETV Success Score (ETVSS)‎

Predicts the probability of ETV success in paediatric hydrocephalus based on age, aetiology, and the presence of a prior shunt. The score runs from 0 to 90, it approximates the probability of ETV success at 6 months.

80
ETVSS
High success probability
Source: Kulkarni AV, et al. Endoscopic third ventriculostomy in the treatment of childhood hydrocephalus. J Pediatr 2009;155(2):254–9.e1. PMID 19446842 · doi:10.1016/j.jpeds.2009.02.048

Spetzler–Martin AVM Grade

Grades cerebral AVMs from 1 to 5 based on three features (the size, the pattern of venous drainage, and the eloquence of the surrounding brain). Correlates with surgical risk. Grade 6 = inoperable.

1
S–M Grade
Low surgical risk
Source: Spetzler RF, Martin NA. A proposed grading system for arteriovenous malformations. J Neurosurg 1986;65(4):476–483. PMID 3760956 · doi:10.3171/jns.1986.65.4.0476

Evans Index

The ratio of the maximum width of the frontal horns of the lateral ventricles to the maximum internal skull diameter on the same axial slice. Used to assess ventriculomegaly. Values > 0.30 are considered abnormal in adults, paediatric thresholds vary by age.

0.29
Evans Index
Normal (≤ 0.30 in adults)‎
Source: Evans WA Jr. An encephalographic ratio for estimating ventricular enlargement and cerebral atrophy. Arch Neurol Psychiatry 1942;47(6):931–937.
On the history of the Evans Index (review): Fleuren KJR, Koehler PJ, Hoff EI. The History of the Evans Index. Eur Neurol 2025;88(2):92–96. Article (Karger) · Evans' original 1942 article (JAMA Network)
Modern interpretation: Toma AK, et al. Evans' index revisited: the need for an alternative in normal pressure hydrocephalus. Neurosurgery 2011;68(4):939–44. PMID 21221031 · doi:10.1227/NEU.0b013e318208f5e0

Pediatric Maintenance Fluids — Holliday–Segar (4-2-1)‎

The hourly maintenance fluid rate based on weight, 4 mL/kg/hr for the first 10 kg, then 2 mL/kg/hr for the next 10 kg, then 1 mL/kg/hr for each kg above 20 kg.

50
mL/hour
≈ 1200 mL/day
Source: Holliday MA, Segar WE. The maintenance need for water in parenteral fluid therapy. Pediatrics 1957;19(5):823–832. PMID 13431307
Note: In patients at risk of SIADH (post-neurosurgery, meningitis, pulmonary disease), full maintenance can cause hyponatraemia. Consider running at ½–⅔ maintenance with sodium monitoring.

Free Water Deficit

Estimates the free water required to correct hypernatraemia. Useful in children with diabetes insipidus after neurosurgery in the pituitary region. The correction rate should not exceed 0.5 mEq/L/hour, to avoid cerebral oedema.

1.3
L free water deficit
Replace slowly — max 0.5 mEq/L/hour
Source: Adrogué HJ, Madias NE. Hypernatremia. N Engl J Med 2000;342(20):1493–1499. PMID 10816188 · doi:10.1056/NEJM200005183422006
Formula: FWD (L) = TBW × ((Nacurrent / Natarget) − 1)

Modified Rankin Scale (mRS)‎

A functional outcome scale used after stroke or brain injury. Seven grades from 0 to 6. Widely used in neurosurgical trials and research.

0
mRS
Excellent outcome
Source: van Swieten JC, et al. Interobserver agreement for the assessment of handicap in stroke patients. Stroke 1988;19(5):604–7. PMID 3363593 · doi:10.1161/01.str.19.5.604

Hemorrhage Volume & Scoring

Hematoma volume measurement (epidural, subdural, intracerebral) and prognostic scoring.

ABC/2 Hematoma Volume

A rapid estimation of intracranial haematoma volume on CT. Applies to epidural (EDH), subdural (SDH), and intracerebral (ICH) haematomas. Volume = (A × B × C) ÷ 2, where A = largest diameter, B = diameter perpendicular to A, C = cranio-caudal extent, all measured in cm.

18
mL (approx.)
Moderate volume

Clinical note — surgical evacuation thresholds: Per the Brain Trauma Foundation (BTF) surgical-management guidelines, an epidural haematoma (EDH) greater than 30 cm³ should be evacuated regardless of GCS, and an acute subdural haematoma (ASDH) should be evacuated if its thickness exceeds 10 mm or the midline shift exceeds 5 mm. These remain guideline thresholds, to be integrated with the full clinical picture and the patient's neurological status.

Sources: Kothari RU, et al. The ABCs of measuring intracerebral hemorrhage volumes. Stroke 1996;27(8):1304–5. PMID 8711791 · doi:10.1161/01.str.27.8.1304
Bullock MR, et al. Surgical management of acute epidural hematomas. Neurosurgery 2006;58(3 Suppl):S7–S15. PMID 16710967
Bullock MR, et al. Surgical management of acute subdural hematomas. Neurosurgery 2006;58(3 Suppl):S16–S24. PMID 16710968

ICH Score (Hemphill)‎

Predicts the 30-day mortality after spontaneous intracerebral haemorrhage in adults. Five components, score 0 to 6. Not formally validated in paediatrics.

0
ICH Score
30-day mortality: 0%
Source: Hemphill JC III, et al. The ICH score: a simple, reliable grading scale for intracerebral hemorrhage. Stroke 2001;32(4):891–897. PMID 11283388 · doi:10.1161/01.str.32.4.891
30-day mortality rates from the original cohort: 0 → 0%, 1 → 13%, 2 → 26%, 3 → 72%, 4 → 97%, 5 → 100%, 6 → 100%.

Pediatric ICH Score (Beslow)‎

A simple grading scale for spontaneous intracerebral haemorrhage in children. Four components, score 0 to 5. Predicts a poor functional outcome (mRS ≥ 3) at discharge.

0
Pediatric ICH Score
Low risk of poor outcome
Source: Beslow LA, et al. Pediatric intracerebral hemorrhage score: a simple grading scale for intracerebral hemorrhage in children. Stroke 2014;45(1):66–70. PMID 24281231 · doi:10.1161/STROKEAHA.113.003448

Neurosurgery Drug Doses

Important caution. Drug doses carry a higher responsibility for error than any other section here. Always verify against your local protocol and pharmacy for each patient. Maximum doses, infusion limits, and contraindications are stated for each drug, they do not replace clinical judgment.

Dexamethasone — for peritumoral edema

A potent long-acting corticosteroid. Reduces the oedema around brain tumors and tumor-like lesions. Not effective for trauma-related or ischaemic brain oedema.

10
mg per dose
= 2.5 mL of 4 mg/mL
Clinical notes:
  • Pediatric max: typically 16 mg/day divided (some protocols allow more).
  • If used > 7 days, taper to avoid adrenal suppression.
  • Give with a gastric protectant (e.g., omeprazole).
  • Monitor glucose daily — rises significantly.
  • Not indicated in TBI (CRASH 2004 — harm).

Reference: Roth P, et al. Corticosteroid use in neuro-oncology: an update. Neurooncol Pract 2015;2(1):6–12. PMID 26034636 · doi:10.1093/nop/npu029

Mannitol — for raised ICP

An osmotic agent that draws water from the brain into the intravascular space. Used in acute raised ICP, impending herniation, and as part of neurosurgical preparation.

10
g per dose
= 50 mL of 20% mannitol
Clinical notes:
  • Infuse over 15–30 minutes (avoid rapid bolus).
  • May repeat q4–6h if ICP remains elevated.
  • Monitor serum osmolality — hold if > 320 mOsm/kg.
  • Monitor renal function, Na⁺, K⁺ — may cause dehydration and renal failure.
  • Foley catheter required — causes profound diuresis.
  • Rebound rise in ICP possible on abrupt cessation.

Reference: Kochanek PM, et al. Guidelines for the Management of Pediatric Severe Traumatic Brain Injury, Third Edition. Pediatr Crit Care Med 2019;20(3S):S1–S82. PMID 30829890 · doi:10.1097/PCC.0000000000001735

Hypertonic Saline 3%‎

An alternative (or an adjunct) to mannitol for ICP control. Preferred in hypovolaemic or renally impaired patients. A central line is preferred, but a short peripheral bolus is acceptable in an emergency.

100
mL (bolus)
Target Na⁺ 145–160 mEq/L
Clinical notes:
  • Monitor Na⁺ q4–6h; max correction rate 0.5 mEq/L/hr to avoid osmotic demyelination / brain shrinkage.
  • Monitor osmolality — hold if > 360 mOsm/kg.
  • If baseline hyponatremic (chronic), correct much more slowly.
  • Central line preferred for continuous infusion.
  • Monitor for fluid overload and pulmonary edema.

Reference: Kochanek PM, et al. Pediatric severe TBI guidelines, 3rd ed. Pediatr Crit Care Med 2019;20(3S):S1–S82. PMID 30829890 · doi:10.1097/PCC.0000000000001735

Phenytoin — Loading Dose

An anticonvulsant used for post-craniotomy seizure prophylaxis or for the control of acute seizures. Fosphenytoin is preferred when it is available, because of its better IV safety profile.

400
mg — loading dose
Max rate 1 mg/kg/min (peds; max 50 mg/min adults)
Clinical notes:
  • Loading: 20 mg/kg IV (max usually 1000–1500 mg).
  • Maintenance: 5–8 mg/kg/day divided q8–12h.
  • Continuous ECG and BP monitoring during loading — risk of arrhythmia and hypotension.
  • Dilute in normal saline only (precipitates in glucose).
  • Check level 2 hr after loading complete (target 10–20 μg/mL total, 1–2 free).
  • Avoid peripheral arterial line / risk of \"purple glove syndrome.\"

Reference: Glauser T, et al. Evidence-based guideline: treatment of convulsive status epilepticus in children and adults. Epilepsy Curr 2016;16(1):48–61. PMID 26900382 · doi:10.5698/1535-7597-16.1.48

Levetiracetam (Keppra) — Loading Dose

An alternative anticonvulsant to phenytoin, with a better safety profile, fewer drug interactions, and no need for routine level monitoring. It is increasingly preferred for post-operative prophylaxis and for status epilepticus.

1200
mg
Infuse IV over 15 minutes
Clinical notes:
  • Maintenance: 20–60 mg/kg/day divided q12h (max 3000 mg/day adult).
  • Renal dose adjustment required for CrCl < 80 mL/min.
  • Monitor behavioural changes — irritability, aggression, depression are common.
  • Can be given PO or IV at the same dose (100% bioavailability).

Reference: Kapur J, et al. (ESETT Group). Randomized trial of three anticonvulsant medications for status epilepticus. N Engl J Med 2019;381(22):2103–2113. PMID 31774955 · doi:10.1056/NEJMoa1905795

Cefazolin — Pre-op Neurosurgical Prophylaxis

The standard pre-operative prophylactic antibiotic for craniotomy, shunt insertion, and most clean neurosurgical operations. Administered within 60 minutes of the incision and re-dosed every 4 hours intraoperatively.

600
mg IV pre-incision
Re-dose every 4 hours intraop
Clinical notes:
  • Dose: 30 mg/kg (max 2 g; 3 g if weight > 120 kg).
  • Timing: within 60 minutes of incision.
  • For severe penicillin allergy or MRSA risk: vancomycin 15 mg/kg (max 2 g) within 120 min of incision.
  • Do not extend prophylaxis beyond skin closure in clean cases.

Reference: Bratzler DW, et al. Clinical practice guidelines for antimicrobial prophylaxis in surgery. Am J Health Syst Pharm 2013;70(3):195–283. PMID 23327981 · doi:10.2146/ajhp120568

Normal CSF Values by Age

A reference table, the values can vary by laboratory method, verify against your local reference values.

Age WBC (/mm³) Protein (mg/dL) Glucose (mg/dL) Opening pressure (cm H₂O)
Neonate0–3020–17030–1208–11
Infant (> 1 month)0–1015–4540–8010–18
Older child0–515–4540–8010–25
Adolescent / adult0–515–4550–8010–25
CSF glucose is typically 60–70% of serum glucose; a CSF:serum ratio < 0.4 suggests bacterial meningitis.
References: Kestenbaum LA, et al. Defining cerebrospinal fluid white blood cell count reference values in neonates and young infants. Pediatrics 2010;125(2):257–64. PMID 20064869 · doi:10.1542/peds.2009-1181
Shah SS, et al. Age-specific reference values for cerebrospinal fluid protein concentration in neonates and young infants. J Hosp Med 2010;6(1):22–7. PMID 20629018 · doi:10.1002/jhm.711

Lansky Performance Status (Pediatric)

For children from 1 to 16 years of age. Based on parent observation of the level of play and activity.

%Description
100Fully active, normal
90Minor restrictions in strenuous physical activity
80Active but tires more quickly
70Both greater restriction of and less time spent in active play
60Up and around but minimal active play; keeps busy with quieter activities
50Gets dressed but lies around most of the day; no active play
40Mostly in bed; participates in quiet activities
30In bed; needs assistance even for quiet play
20Often sleeping; play entirely limited to very passive activities
10No play; does not get out of bed
0Unresponsive
Source: Lansky SB, et al. The measurement of performance in childhood cancer patients. Cancer 1987;60(7):1651–1656. PMID 3621134

Karnofsky Performance Status (KPS)

For adolescents and adults. Used in oncology trials, in the assessment of surgical eligibility, and in outcome follow-up.

%Description
100Normal; no complaints; no evidence of disease
90Able to carry on normal activity; minor symptoms
80Normal activity with effort; some symptoms
70Cares for self; unable to carry on normal activity or work
60Requires occasional assistance; cares for most needs
50Requires considerable assistance and frequent medical care
40Disabled; requires special care and assistance
30Severely disabled; hospitalization indicated
20Very sick; active supportive treatment necessary
10Moribund; fatal processes progressing rapidly
0Dead
Original description of the scale: Karnofsky DA, Burchenal JH. The clinical evaluation of chemotherapeutic agents in cancer (the paper in which the Karnofsky Performance Status was first described). In: MacLeod CM (ed), Evaluation of Chemotherapeutic Agents. Columbia University Press, New York, 1949:191–205. (pre-PubMed — no link)
Reliability, validity & guidelines: Schag CC, Heinrich RL, Ganz PA. Karnofsky performance status revisited: reliability, validity, and guidelines. J Clin Oncol 1984;2(3):187–93. PMID 6699671 · doi:10.1200/JCO.1984.2.3.187