Pediatric Stroke & Moyamoya

When the brain's blood supply is in trouble

Important. This is general educational information. Your child's situation is unique. Always talk to your child's treating doctor for advice that fits your child specifically.

Most people are surprised to hear that children can have strokes. They can, at any age, from before birth through the teenage years. This page explains what paediatric stroke is, what the underlying causes can be (including a particular condition called moyamoya), how it is diagnosed, and what the treatment can do. Your child's neurology and neurosurgery team will discuss what applies specifically to your child.

What is pediatric stroke?

A stroke happens when part of the brain suddenly loses its blood supply. There are two main ways this can happen. An ischaemic stroke is when an artery to the brain is blocked, usually by a clot, and the brain tissue beyond the block does not receive enough oxygen. A haemorrhagic stroke is when a blood vessel in the brain bursts and bleeds into the surrounding tissue. Both can cause sudden, dramatic symptoms.

Paediatric stroke is not just "adult stroke in a smaller body". The causes are very different. The most common reasons for a child to have a stroke include congenital heart disease, sickle cell disease, narrowing of brain arteries (such as moyamoya, described below), abnormal blood vessels in the brain (such as arteriovenous malformations or cavernous malformations), trauma to the neck arteries, infections, or inherited problems with blood clotting. In some children, no clear cause is ever found, even after thorough investigation.

Moyamoya deserves a particular mention because it is a condition in which neurosurgery can directly prevent future strokes. In moyamoya, the large arteries at the base of the brain become slowly and progressively narrower. As they narrow, tiny new vessels grow to try to compensate. On a particular imaging study, these new vessels look like a puff of smoke, and "moyamoya" is the Japanese phrase for a puff of smoke. Children with moyamoya often have repeated mini-strokes (called transient ischaemic attacks, or TIAs) before a larger stroke. Moyamoya can occur on its own or together with another condition (most commonly sickle cell disease, neurofibromatosis type 1, Down syndrome, or after radiation to the head).

Arteriovenous malformations (AVMs) are another important cause, tangles of abnormal blood vessels that can bleed and cause a haemorrhagic stroke. Cavernous malformations and aneurysms are rarer but possible. Your child's team will tell you which of these applies to your child.

Signs of stroke and when to act

The most important thing parents and caregivers can know is how to recognise a stroke, because every minute matters. The simple word "FAST" is used worldwide as a memory aid for the main signs - Face (sudden drooping on one side), Arm (sudden weakness in one arm or leg), Speech (sudden difficulty speaking, slurred speech, or difficulty understanding), Time (call for emergency help right away). In children, you may also see specific patterns:

In babies

  • A baby who suddenly stops moving one side of the body, or who always seems to use only one hand (very early hand preference can sometimes be a sign of an earlier stroke)
  • Sudden onset of seizures, particularly when the baby seems otherwise well between the seizures
  • Becoming unusually drowsy, hard to rouse, or unresponsive
  • A bulging fontanelle or rapidly increasing head size in a baby (can suggest bleeding inside the head)
  • Persistent crying that nothing comforts, refusal to feed, or repeated vomiting

In older children

  • Sudden weakness or numbness of the face, the arm, or the leg, especially on one side
  • Sudden difficulty speaking, slurred speech, or difficulty understanding what is being said
  • A sudden, very severe headache, often described as "the worst headache of my life" (this can be a sign of bleeding)
  • Sudden loss of balance, dizziness, or difficulty walking
  • Sudden visual changes, double vision, blurry vision, or loss of part of the visual field
  • A new seizure, particularly in a child who has never had seizures before
  • Becoming confused or unusually drowsy
  • In moyamoya specifically - short episodes (lasting minutes) of one-sided weakness, numbness, or speech trouble, often triggered by crying, blowing on hot food, vigorous exercise, or anything that involves fast deep breathing

How is it diagnosed?

Paediatric stroke is a medical emergency. In the emergency department, the first task is to find out which type of stroke it is and what is causing it. A CT-scan is often the first test because it is fast and can show bleeding clearly. An MRI of the brain is then performed, sometimes immediately, sometimes after the child is stable, because the MRI shows the stroke itself far better than CT.

Once a stroke is confirmed, attention turns to the blood vessels. An MR angiogram (MRA) uses MRI to show the brain's arteries. Sometimes a CT angiogram (CTA) is used instead. For more detailed views, particularly when moyamoya, an AVM, or an aneurysm is suspected, a conventional cerebral angiogram is performed. This involves passing a thin tube (catheter) into an artery, usually through the groin, and taking detailed pictures of every vessel feeding the brain. It is the most detailed test of all and gives the surgical team the information needed to plan treatment.

Other tests look for the cause. An echocardiogram (an ultrasound of the heart) checks for heart problems that can throw clots up to the brain. Blood tests look for clotting disorders, sickle cell disease, and certain infections. A neck ultrasound or scan may be performed to assess for injury to the neck arteries. Depending on the picture, genetic testing or other specialist studies may also be performed.

A neurological examination is repeated frequently in the early days because the picture can change quickly. The team uses standard scales to measure the impact of the stroke on your child.

How is it treated?

Treatment of paediatric stroke has two parts, the care of the brain in the acute phase, and the treatment of the underlying cause to prevent another stroke. The right plan depends entirely on the type of stroke and the cause.

Emergency care in the acute phase

In the first hours and days, the team works to protect the brain. This usually involves careful control of blood pressure, oxygen, and blood sugar, treatment of seizures if they occur, and close monitoring, often in the paediatric intensive care unit (PICU). Some children with large ischaemic strokes are now treated with clot-removing or clot-dissolving therapies at specialised centres, although these treatments are used more cautiously in children than in adults. If there is severe brain swelling from a large stroke, a temporary operation to relieve the pressure (decompressive craniectomy) is sometimes needed.

Treating the cause to prevent another stroke

Once your child is stable, the team works on what caused the stroke and how to prevent another. Children with heart-related stroke are managed alongside the cardiology team. Children with sickle cell disease often need regular blood transfusions or a medication called hydroxyurea, along with neurology follow-up. Children with clotting disorders may need blood-thinning medication. The goal is to address the specific cause, there is no single "stroke prevention" plan that fits every child.

Surgery for moyamoya — revascularization

For moyamoya, the most effective treatment is an operation that creates a new blood supply to the brain, called revascularisation. The neurosurgeon uses one of the scalp's healthy arteries (most commonly the superficial temporal artery) and either connects it directly to a brain artery (a direct bypass) or simply lays it gently onto the surface of the brain (an indirect procedure called pial synangiosis or EDAS). The brain then grows new tiny vessels into this new blood supply over the following months. The operation does not reverse damage that has already occurred, but it dramatically reduces the risk of further strokes. The indirect procedures are most often used in younger children, the direct bypasses are more common in older children and adults.

Treatment for AVM, cavernous malformation, or aneurysm

These vascular conditions are usually treated to prevent (or stop further) bleeding. There are three main tools, often used in combination - microsurgery to remove the abnormal vessels, endovascular embolisation (blocking the abnormal vessels through a catheter passed in the groin), and radiosurgery (focused radiation that closes the abnormal vessels over months without an open operation). The right combination depends on the size, the location and the shape of the malformation, and on your child's age. This is a decision the cerebrovascular team makes carefully and explains in detail.

Rehabilitation

From the earliest days, rehabilitation begins, physiotherapy, occupational therapy, speech and language therapy, and (later) neuropsychology. The brains of children are remarkably good at rerouting and adapting, particularly when rehabilitation starts early. Many children make recoveries that surprise their families and their teams.

For children with moyamoya, day-to-day precautions also matter, avoiding dehydration, avoiding situations that cause fast deep breathing (such as blowing up balloons, or crying for long periods where this can be prevented), and seeking quick medical attention for any new neurological symptoms. The team will give you a specific plan for your child.

What can we expect during recovery?

Recovery from a paediatric stroke depends very much on the size and the location of the stroke, on how quickly treatment was started, and on the underlying cause. The first few weeks in hospital focus on protecting the brain, treating the cause, and beginning rehabilitation. Many children show small but real improvements in the first days, others take weeks or months to begin to recover.

The brains of children have a remarkable ability to adapt, the medical word for it is plasticity. Functions affected by a stroke can sometimes be taken over by other parts of the brain, particularly in younger children. This is the reason that recoveries from paediatric stroke are often better than adult recoveries from a similar injury. The plasticity is not unlimited, however, large strokes or strokes in critical areas leave lasting differences, and the recovery is usually a slow process.

Specialists you and your child may work with over the coming months and years include paediatric neurology, neurosurgery, haematology (for sickle cell or clotting disorders), cardiology (for heart-related causes), physiotherapy, occupational therapy, speech-language therapy, neuropsychology, ophthalmology, and orthopaedics. A coordinator or a case manager often helps make sense of all the appointments.

School matters a great deal. Many children return to mainstream school with adjustments, extra time, support for one-sided weakness, breaks for fatigue, or specific learning support. A formal neuropsychological assessment is often performed some months after the stroke to map out exactly which abilities have been affected and to plan school support around them.

For children with moyamoya who have undergone revascularisation surgery, follow-up usually includes regular clinical reviews and imaging (MRI/MRA, and sometimes a repeat angiogram) to confirm that the new blood supply is functioning. Most children with a successful revascularisation go on to live full lives with very low risk of further strokes.

The emotional toll on the family is real and is not separate from the medical care. Family support groups, mental health support, and connection with other families who have travelled this path are part of the picture, not extras.

Questions you might ask your child's doctor

  • What type of stroke has my child had, ischaemic or haemorrhagic, and where in the brain is it?
  • What do you think caused the stroke? Is the underlying cause still active, or was it a one-off event?
  • Does my child have moyamoya, an AVM, or another vascular condition that needs specific treatment?
  • Will my child need an operation? If so, which one, direct bypass, indirect revascularisation, AVM treatment, and why?
  • What medications will my child be on, and for how long? Aspirin, blood thinners, sickle cell medications?
  • What is the risk of another stroke, and what can we do at home to reduce that risk?
  • What rehabilitation will my child need, and where will it happen, inpatient or outpatient?
  • When can my child return to school, and what support will they need?
  • Are there activities or situations to avoid, sport, dehydration, hyperventilation, certain medicines?
  • Who is on my child's long-term team, and who do we contact between appointments?

When to call your child's doctor right away

After a stroke or after stroke surgery, certain signs can mean that another stroke is happening, that a TIA is occurring, or that a complication has developed. Do not wait, call the emergency services or go to the nearest emergency department right away if you notice any of the following:

  • Sudden weakness, numbness, or drooping of the face, the arm, or the leg, especially on one side
  • Sudden difficulty speaking, slurred speech, or difficulty understanding speech
  • A sudden, very severe headache, particularly if it feels different from previous headaches
  • Sudden loss of balance, severe dizziness, or difficulty walking
  • Sudden loss of vision, double vision, or new blurring of vision
  • A seizure, or any change in your child's usual seizure pattern
  • Becoming unusually drowsy, difficult to rouse, or confused
  • Repeated vomiting, particularly when associated with severe headache
  • Redness, swelling, fluid leaking, or pain at a surgical scar (in children who have had revascularisation or AVM surgery)
  • Any episode of one-sided weakness, numbness, or speech difficulty, even if it improves within minutes (this is a TIA and is a warning sign of another stroke)

If your child is unconscious, is having a seizure, or is having difficulty breathing, this is an emergency, call the emergency services immediately. For any stroke symptom, time matters, the faster the team sees your child, the more they can do.

More information from trusted sources

  • Children's Hemiplegia and Stroke Association (CHASA) — A US-based non-profit dedicated to supporting families of children affected by stroke and hemiplegia, with comprehensive plain-language information, family connections, and youth programmes.
    https://www.chasa.org ↗
  • International Alliance for Pediatric Stroke (IAPS) — An international network of paediatric stroke patient organisations, with educational resources, a focus on early recognition, and links to support organisations in many countries.
    https://iapediatricstroke.org ↗
  • Stroke Association (UK) — The UK's national stroke charity, with a section dedicated to childhood stroke, a helpline, and detailed information for families and schools.
    https://www.stroke.org.uk ↗
  • American Association of Neurological Surgeons — Patient Information — The patient education pages of the professional society, with overviews of stroke, moyamoya, arteriovenous malformations, and cerebrovascular conditions in plain language.
    https://www.aans.org/Patients/Neurosurgical-Conditions-and-Treatments ↗
  • HealthyChildren.org (American Academy of Pediatrics) — Trusted patient and family information from the American Academy of Pediatrics, covering many paediatric conditions including stroke and sickle cell disease.
    https://www.healthychildren.org ↗